Research Brief
Storing CJC-1295 No Dac: Best Practices
Pó Liofilizado
Store at -20°C for estabilidade a longo prazo. The liofilizado form is estavel at refrigerated temperatures (2–8°C) or even room temperature for shorter periods but deve ser kept sealed, away from moisture and direto(a) light for optimal preservation.
Solução Reconstituída
Reconstitua com agua bacteriostatica (preferred for multi-use) or sterile water for injection. Uma vez reconstituído, refrigerate at 2–8°C and use dentro de 14–28 days depending no(a) solvent used and storage conditions. Bacteriostatic water generally allows longer storage comparado(a) a sterile water.
Manuseio
White to off-white liofilizado powder. When reconstituting, inject the solvent slowly down the side do(a) vial and agite suavemente em movimentos circulares — do NOT shake, as this may damage o peptideo structure. Purity: ≥98% by RP-HPLC. Identity: LC-MS/MS (~3367.95 Da). The tetrasubstitution modifications provide resistance to DPP-4 enzymatic degradacao, extending functional meia-vida to aproximadamente 30 minutes do(a) mere minutes characteristic of native GHRH.
Referencias
- Henninge J, Pepaj M, Hullstein I, Hemmersbach P. Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation. Drug Testing and Analysis, 2(11-12), 647-650, 2010.
- Soule S, King JA, Millar RP. Incorporation of D-Ala2 in hormonio do crescimento-releasing hormone-(1-29)-NH2 aumenta the meia-vida and diminui metabolic depuracao in normal men. The Journal of Clinical Endocrinology and Metabolism, 79(4), 1208-1211, 1994.
- Hartvig RA, Holm NB, Dalsgaard PW, Reitzel LA, Müller IB, Linnet K. Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013. Scandinavian Journal of Forensic Science, 20(2), 42-49, 2014.
- Jetté L, et al. Human Growth Hormone-Releasing Factor (hGRF)1-29-Albumin Bioconjugates Activate the GRF Receptor no(a) Anterior Pituitary in Rats: Identification of CJC-1295 como um(a) Long-Lasting GRF Analog. Endocrinology, 146(7), 3052-3058, 2005.
- Lance VA, Murphy WA, Sueiras-Diaz J, Coy DH. Super-active analogs of hormonio do crescimento-releasing factor (1-29)-amide. Biochemical and Biophysical Research Communications, 119(1), 265-272, 1984.
- Van Hout MC, Hearne E. Netnography of Female Use do(a) Synthetic Growth Hormone CJC-1295: Pulses and Potions. Substance Use & Misuse, 51(1), 73-84, 2016.
- Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sexual Medicine Reviews, 6(1), 45-53, 2018.
- Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged estimulacao of hormonio do crescimento (GH) and insulin-like fator de crescimento I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in adultos saudaveis. The Journal of Clinical Endocrinology & Metabolism, 91(3), 799-805, 2006.
- Food and Drug Administration. FDA Evaluation of CJC-1295 Related Substancia Farmaceutica a Granels. FDA Briefing Document: Pharmacy Compounding Advisory Committee (PCAC) Meeting, December 4, 2024.
- Food and Drug Administration. Final Summary Minutes do(a) Pharmacy Compounding Advisory Committee Meeting. Center for Drug Evaluation and Research, December 4, 2024.
- World Anti-Doping Agency. The 2024 Lista de Substancias Proibidas: International Standard. World Anti-Doping Code, 2024.
- Sinha DK, Balasubramanian A, Tatem AJ, Kovac JR, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of hormonio do crescimento secretagogues no(a) modern management of composicao corporal in hypogonadal males. Translational Andrology and Urology, 9(Suppl 2), S149-S159, 2020.
- Fabresse N, Grassin-Delyle S, Etting I, Alvarez JC. Identification of a GHRH peptide analogue, the CJC-1295, using LC-HRMS/MS. Toxicologie Analytique et Clinique, 29(2), 205-211, 2017.
- Ben-Shlomo A, et al. DNA damage and hormonio do crescimento hypersecretion in pituitary somatotroph adenomas. The Journal of Clinical Investigation, 130(11), 5738-5755, 2020.
- Ionescu M, Frohman LA. Pulsatile secretion of hormonio do crescimento (GH) persists during continuous estimulacao by CJC-1295, a long-acting GH-releasing hormone analog. The Journal of Clinical Endocrinology & Metabolism, 91(12), 4792-4797, 2006.
- Memdouh S, Gavrilović I, Ng K, Cowan D, Abbate V. Advances no(a) detection of hormonio do crescimento releasing hormone synthetic analogs. Drug Testing and Analysis, 13(11-12), 1871-1887, 2021.
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